It is the first to estimate the effectiveness of a third dose of Pfizer-BioNTech mRNA COVID-19 vaccine against severe outcomes with adjustment for various possible confounders, including comorbidities and behavioural factors. A recent clinical trial conducted by BioNTech included a smaller sample size and did not estimate the third-dose's effects for more severe outcomes.
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» Covid booster dose effective in reducing severe disease outcomes: Lancet study
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